抗微生物抗性(AMR)是日益增长的公共卫生威胁,估计每年造成超过1000万人死亡,在现状预测下,到2050年,全球经济损失了100万亿美元。这些损失主要是由于治疗失败的发病率和死亡率增加,医疗程序中的AMR感染以及归因于AMR的生活质量损失所致。已经提出了许多干预措施来控制AMR的发展并减轻其传播带来的风险。本文回顾了细菌AMR管理和控制的关键方面,这些方面可以利用人工智能,机器学习以及数学和统计建模等数据技术,这些领域在本世纪已经快速发展。尽管数据技术已成为生物医学研究的组成部分,但它们对AMR管理的影响仍然很小。我们概述了使用数据技术来打击AMR,详细介绍了四个互补类别的最新进展:监视,预防,诊断和治疗。我们在生物医学研究,临床实践和“一个健康”背景下使用数据技术提供了有关当前AMR控制方法的概述。我们讨论了数据技术的潜在影响和挑战在高收入和中等收入国家中面临的实施,并建议将这些技术更容易地整合到医疗保健和公共卫生中所需的具体行动,并建议使用具体的行动部门。
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The visual dimension of cities has been a fundamental subject in urban studies, since the pioneering work of scholars such as Sitte, Lynch, Arnheim, and Jacobs. Several decades later, big data and artificial intelligence (AI) are revolutionizing how people move, sense, and interact with cities. This paper reviews the literature on the appearance and function of cities to illustrate how visual information has been used to understand them. A conceptual framework, Urban Visual Intelligence, is introduced to systematically elaborate on how new image data sources and AI techniques are reshaping the way researchers perceive and measure cities, enabling the study of the physical environment and its interactions with socioeconomic environments at various scales. The paper argues that these new approaches enable researchers to revisit the classic urban theories and themes, and potentially help cities create environments that are more in line with human behaviors and aspirations in the digital age.
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While inferring common actor states (such as position or velocity) is an important and well-explored task of the perception system aboard a self-driving vehicle (SDV), it may not always provide sufficient information to the SDV. This is especially true in the case of active emergency vehicles (EVs), where light-based signals also need to be captured to provide a full context. We consider this problem and propose a sequential methodology for the detection of active EVs, using an off-the-shelf CNN model operating at a frame level and a downstream smoother that accounts for the temporal aspect of flashing EV lights. We also explore model improvements through data augmentation and training with additional hard samples.
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The Internet of Senses (IoS) holds the promise of flawless telepresence-style communication for all human `receptors' and therefore blurs the difference of virtual and real environments. We commence by highlighting the compelling use cases empowered by the IoS and also the key network requirements. We then elaborate on how the emerging semantic communications and Artificial Intelligence (AI)/Machine Learning (ML) paradigms along with 6G technologies may satisfy the requirements of IoS use cases. On one hand, semantic communications can be applied for extracting meaningful and significant information and hence efficiently exploit the resources and for harnessing a priori information at the receiver to satisfy IoS requirements. On the other hand, AI/ML facilitates frugal network resource management by making use of the enormous amount of data generated in IoS edge nodes and devices, as well as by optimizing the IoS performance via intelligent agents. However, the intelligent agents deployed at the edge are not completely aware of each others' decisions and the environments of each other, hence they operate in a partially rather than fully observable environment. Therefore, we present a case study of Partially Observable Markov Decision Processes (POMDP) for improving the User Equipment (UE) throughput and energy consumption, as they are imperative for IoS use cases, using Reinforcement Learning for astutely activating and deactivating the component carriers in carrier aggregation. Finally, we outline the challenges and open issues of IoS implementations and employing semantic communications, edge intelligence as well as learning under partial observability in the IoS context.
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Multi-document summarization (MDS) has traditionally been studied assuming a set of ground-truth topic-related input documents is provided. In practice, the input document set is unlikely to be available a priori and would need to be retrieved based on an information need, a setting we call open-domain MDS. We experiment with current state-of-the-art retrieval and summarization models on several popular MDS datasets extended to the open-domain setting. We find that existing summarizers suffer large reductions in performance when applied as-is to this more realistic task, though training summarizers with retrieved inputs can reduce their sensitivity retrieval errors. To further probe these findings, we conduct perturbation experiments on summarizer inputs to study the impact of different types of document retrieval errors. Based on our results, we provide practical guidelines to help facilitate a shift to open-domain MDS. We release our code and experimental results alongside all data or model artifacts created during our investigation.
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We present a machine-learning framework to accurately characterize morphologies of Active Galactic Nucleus (AGN) host galaxies within $z<1$. We first use PSFGAN to decouple host galaxy light from the central point source, then we invoke the Galaxy Morphology Network (GaMorNet) to estimate whether the host galaxy is disk-dominated, bulge-dominated, or indeterminate. Using optical images from five bands of the HSC Wide Survey, we build models independently in three redshift bins: low $(0<z<0.25)$, medium $(0.25<z<0.5)$, and high $(0.5<z<1.0)$. By first training on a large number of simulated galaxies, then fine-tuning using far fewer classified real galaxies, our framework predicts the actual morphology for $\sim$ $60\%-70\%$ host galaxies from test sets, with a classification precision of $\sim$ $80\%-95\%$, depending on redshift bin. Specifically, our models achieve disk precision of $96\%/82\%/79\%$ and bulge precision of $90\%/90\%/80\%$ (for the 3 redshift bins), at thresholds corresponding to indeterminate fractions of $30\%/43\%/42\%$. The classification precision of our models has a noticeable dependency on host galaxy radius and magnitude. No strong dependency is observed on contrast ratio. Comparing classifications of real AGNs, our models agree well with traditional 2D fitting with GALFIT. The PSFGAN+GaMorNet framework does not depend on the choice of fitting functions or galaxy-related input parameters, runs orders of magnitude faster than GALFIT, and is easily generalizable via transfer learning, making it an ideal tool for studying AGN host galaxy morphology in forthcoming large imaging survey.
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Wearable sensors for measuring head kinematics can be noisy due to imperfect interfaces with the body. Mouthguards are used to measure head kinematics during impacts in traumatic brain injury (TBI) studies, but deviations from reference kinematics can still occur due to potential looseness. In this study, deep learning is used to compensate for the imperfect interface and improve measurement accuracy. A set of one-dimensional convolutional neural network (1D-CNN) models was developed to denoise mouthguard kinematics measurements along three spatial axes of linear acceleration and angular velocity. The denoised kinematics had significantly reduced errors compared to reference kinematics, and reduced errors in brain injury criteria and tissue strain and strain rate calculated via finite element modeling. The 1D-CNN models were also tested on an on-field dataset of college football impacts and a post-mortem human subject dataset, with similar denoising effects observed. The models can be used to improve detection of head impacts and TBI risk evaluation, and potentially extended to other sensors measuring kinematics.
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Deep convolutional neural networks (CNNs) have been widely used for medical image segmentation. In most studies, only the output layer is exploited to compute the final segmentation results and the hidden representations of the deep learned features have not been well understood. In this paper, we propose a prototype segmentation (ProtoSeg) method to compute a binary segmentation map based on deep features. We measure the segmentation abilities of the features by computing the Dice between the feature segmentation map and ground-truth, named as the segmentation ability score (SA score for short). The corresponding SA score can quantify the segmentation abilities of deep features in different layers and units to understand the deep neural networks for segmentation. In addition, our method can provide a mean SA score which can give a performance estimation of the output on the test images without ground-truth. Finally, we use the proposed ProtoSeg method to compute the segmentation map directly on input images to further understand the segmentation ability of each input image. Results are presented on segmenting tumors in brain MRI, lesions in skin images, COVID-related abnormality in CT images, prostate segmentation in abdominal MRI, and pancreatic mass segmentation in CT images. Our method can provide new insights for interpreting and explainable AI systems for medical image segmentation. Our code is available on: \url{https://github.com/shengfly/ProtoSeg}.
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We test grip strength and shock absorption properties of various granular material in granular jamming robotic components. The granular material comprises a range of natural, manufactured, and 3D printed material encompassing a wide range of shapes, sizes, and Shore hardness. Two main experiments are considered, both representing compelling use cases for granular jamming in soft robotics. The first experiment measures grip strength (retention force measured in Newtons) when we fill a latex balloon with the chosen grain type and use it as a granular jamming gripper to pick up a range of test objects. The second experiment measures shock absorption properties recorded by an Inertial Measurement Unit which is suspended in an envelope of granular material and dropped from a set height. Our results highlight a range of shape, size and softness effects, including that grain deformability is a key determinant of grip strength, and interestingly, that larger grain sizes in 3D printed grains create better shock absorbing materials.
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Granular jamming has recently become popular in soft robotics with widespread applications including industrial gripping, surgical robotics and haptics. Previous work has investigated the use of various techniques that exploit the nature of granular physics to improve jamming performance, however this is generally underrepresented in the literature compared to its potential impact. We present the first research that exploits vibration-based fluidisation actively (e.g., during a grip) to elicit bespoke performance from granular jamming grippers. We augment a conventional universal gripper with a computer-controllled audio exciter, which is attached to the gripper via a 3D printed mount, and build an automated test rig to allow large-scale data collection to explore the effects of active vibration. We show that vibration in soft jamming grippers can improve holding strength. In a series of studies, we show that frequency and amplitude of the waveforms are key determinants to performance, and that jamming performance is also dependent on temporal properties of the induced waveform. We hope to encourage further study focused on active vibrational control of jamming in soft robotics to improve performance and increase diversity of potential applications.
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